Unfortunately, the mechanisms of IL-1β secretion by M2 polarised macrophages are largely unknown, although Fcγ receptor (FcγR) signalling might be critical.9 Previously, we demonstrated that certain O-glycosylated proteins from the necrotic debris of cancer cells was sufficient to induce pro-inflammatory M2 polarised TAMs;7 however, the role of IgG in this process is unclear. The gene discussed is IL1B; the disease is cancer.