As shown in Figure 2A, the DEAS that were upregulated in RC were significantly enriched for genes involved in axon guidance (P=0.02), adenosine monophosphate kinase signaling (P=0.009), FoxO signaling (P=0.04), VEGF signaling (P=0.03) and colorectal cancer (P=0.04). This evidence concerns the gene VEGFA and colorectal cancer.