Several parameters have been proposed to affect the secretion and concentration of GLP-1 including glucose [19], fat [19], bile acids [20], inflammatory markers [21, 22], 3-deoxyglucosone [23] (generated from carbohydrates) and the presence of obesity [24] and type 2 diabetes [18]. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.