GLP1R and obesity due to melanocortin 4 receptor deficiency: Endothelial cells do not only play a role in NO production, they also influence on the angiogenesis process [55] and liraglutide has been found to promote angiogenesis after stroke [56] opening up for the possibility that GLP-1-based treatment potentially could be applied as a neuroprotective drug as well as a cardioprotective, anti-hyperglycemic and anti-obesity drug.