Liu et al. (2012) found that a decrease in feed intake in corticosterone-exposed hens was not related to the central or peripheral expression level of CCK. In this study, we found that the gene expression of hypothalamic CCK was significantly decreased by feeding on the HE diet. Obviously, this result is inconsistent with the anorexic effect of CCK. It should be noted that the differences in the translation rate of CCK mRNA are still unknown, and its activity may depend on differential posttranslational processing rather than differential expression (Sayegh et al., 2014). The gene discussed is CCK; the disease is hereditary elliptocytosis.