PALB2 and breast carcinoma: Furthermore, the large amount of functional data presented here can now be used in combination with ongoing initiatives (Boonen, R.A.C.M., et al. Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2 (in press); Wiltshire, T., et al. Functional characterization of 84 PALB2 variants of uncertain significance (in press)) and computational predictive tools to aid determining more accurately the deleteriousness for PALB2 missense variants.