MTOR and neoplasm: Several dual mTOR/PI3 K—kinase inhibitors, such as NVP-BEZ235, BEZ235, and GDC-0980, PF-04691502, XL765, GSK2126458, PI-103, and a different class of mTOR inhibitors (e.g., Torin1, PP242, PP30, Ku-0063794, WAY-600, WYE-687, WYE-354, and CC-223) are currently being developed for clinical use on the assumption that blockade of two different crucial nodes along the PI3 K signaling pathway might result in more complete pathway inhibition, disruption of pathway-reactivating feedback loops, and eventually enhanced anti-tumor activity [3].