The data of Conciatori et al. [3] as well as our previous studies on the use of protein kinase inhibitors in melanoma cells confirmed the efficacy of mTOR inhibitors: rapamycin and everolimus in inhibiting their proliferation and cell cycles [6], induction of apoptosis and in combination with knock down of N-cadherin gene decreased invasiveness [7]. Here, WEE1 is linked to melanoma.