The results of meta-analysis [24] which included 46 randomized controlled trials with a total of 15,511 patients and more than 100 arms suggest that the addition of PI3 K/AKT/mTOR pathway inhibitor to the therapy regimens for advanced solid tumors significantly improved the progression-free survival, especially among patients with breast cancer and neuroendocrine tumors, as well as those with PI3 K mutations. Here, AKT1 is linked to neuroendocrine neoplasm.