Five potential linkage disequilibrium (LD) blocks were constructed based on the r-square value and log-odds score (Fig. 1), and statistical analysis results indicated that patients carrying haplotype C-C in block 4 (rs2001350–rs6726395, in NRF2) had a higher risk of liver injury (adjusted OR = 2.503, 95% CI: 1.273–4.921, P = 0.008), and patients carrying haplotype C-G-C in block 3 (rs2267373-rs4444637-rs4821767, in MAFF) had a lower risk of liver injury (adjusted OR = 0.753, 95% CI: 0.587–0.965, P = 0.025) (Table 4). The gene discussed is NFE2L2; the disease is injury.