MTHFR genotype-sex-risk factors interactions revealed that stroke risk in women ≥6.1 mmol/L of FPG (Fig. 1) or ≥2.3 mmol/L of TG (Fig. 2) with TT genotype was the strongest, and men interacted with TT genotype and SBP ≥160 mmHg (Fig. 3) on increased risk of stroke (Table 5). Here, MTHFR is linked to Stroke.