Consistent with our observations in cell lines, NRARP forced expression in NOTCH1 mutant/NICD1 high T-ALL samples negatively impacted cell number (Fig. 5a) and viability (Fig. 5b), whereas it had the opposite effect on NOTCH1 wild type/NICD low cases (Fig. 5a, b). The gene discussed is NRARP; the disease is acute lymphoblastic leukemia.