The fact that proliferation is potentiated by the chemical inhibition of Wnt signaling and by LEF1 silencing in NOTCH1-mutant DND4.1 and MOLT-4 cells is in agreement with the latter studies, and suggests that Wnt signaling may be detrimental for T-ALL cells with NOTCH1 constitutive activation. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.