IGF2 and ependymoma: Specific genes consistent with studies of human ependymoma samples showed expression level changes4, including upregulated insulin growth factor 2 (IGF2), vascular endothelial growth factor-A (VEGFA), vimentin, matrix metalloproteinase 9 (MMP9) and MMP231 and downregulated mature neuronal maker, microtubule associated protein 2 (MAP2) in fetal ECM-enriched cultures when compared to unsupplemented collagen cultures (Supplementary Figs. 4, 5).