GBM, on the other hand, grew primarily as spheres within the silk scaffold-hydrogel constructs along with visibly more disperse cells within the fetal ECM-enriched hydrogels (Fig. 2a, c, Supplementary Fig. 1); however, there was little to no migration of GBM cells within the central window of CLG1-based constructs at earlier time points. Here, MMP8 is linked to glioblastoma.