In the polyclonal tumors, subclonal mutations with VAF < 0.05 were detected in several genes commonly mutated in DLBCL including a frameshift variant in S1PR2 and missense mutations in GNA13, NOTCH2, CREBBP, EP300, SOCS1, and BCL6 (Fig. 7c) (Supplementary Data 3). The gene discussed is CREBBP; the disease is diffuse large B-cell lymphoma.