MYC and lymphoma: Notably, most synthetic tumors sat in a position intermediate between DLBCL and Burkitt lymphoma, a finding consistent with the forced expression of MYC. Indeed, we saw the strong enrichment for two recently described signatures of MYC-driven lymphoma (double hit signature33 or molecular high-grade signature34; Fig. 6b, Supplementary Table 1) suggesting that the particular oncogenic backbone used to create these tumors, generated models with a gene expression profile that closely approximates double hit lymphoma.