S1PR2 and cancer: Of the 12 most enriched genes (TP53, GNA13, CDKN2A, ATRX, NFKBIA, ZFP36L1, ZNF281, PTEN, FBXO11, FUBP1, S1PR2, and NFKBIE), the majority are associated with a tumor suppressor function in lymphoma, established in the literature either from evidence of recurrent genetic inactivation or from their ability to inhibit cancer-promoting pathways2,7,25,37.