BMP pathway inhibition using LDN193189 (LDN, an inhibitor of all BMP type 1 receptors, but with highest affinity for ACVR1)23,34 and BMPR1a-FC (a ligand trap with the FC domain of IgG1 attached to BMPR1a, leading to ligand removal) increased bone volume, decreased osteoclastogenesis and increased osteoblast differentiation in myeloma-bearing mice. Here, ACVR1 is linked to plasma cell myeloma.