Although LDN and BMPR1a-FC reduced hepcidin expression in vitro, and have reduced anaemia in inflammatory anaemia models53, neither approach increased haemoglobin in 5TGM1 myeloma-bearing mice, but BMPR1a-Fc did increase haemoglobin in JJN-3 myeloma-bearing mice. This evidence concerns the gene HAMP and plasma cell myeloma.