Mouse studies suggest that the overexpression of CtBP in human cancer is likely causally linked to poor prognosis, as we have shown that in mice mutated for Apc (“Apc min”) that otherwise die within a few months from extensive intestinal polyposis, Ctbp2 haploinsufficiency significantly prolongs survival and reduces polyposis by 90%8. This evidence concerns the gene CTBP2 and polyposis.