Thus, it was the aim of this retrospective study to evaluate, in anovulatory women with PCOS, whether baseline levels of luteinizing hormone (LH), FSH, AMH, and androgens would change during the course of two cycles of CC stimulation that did not lead to a pregnancy, and to compare these patients to anovulatory women with PCOS who had chosen an observational approach. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.