The RT-qPCR results showed that CCNB1 (p < 0.01) and N-cadherin (p < 0.01) were overexpressed in the invasive pituitary adenomas compared to the non-invasive pituitary adenomas and that E-cadherin (p < 0.001) expression was significantly decreased (Fig. 2a). The gene discussed is CDH2; the disease is pituitary gland adenoma.