The genes that were significantly downregulated in the NPC samples (Fig 4A-1) as compared to the gastric samples that are involved in migration, invasion, and epithelial differentiation had predicted upstream regulators CBX5, CYP1B1, ETS2, TGFB1, BMP4, SYVN1, IFNG, and SMARCA4. The gene discussed is CBX5; the disease is nasopharyngeal carcinoma.