This region was composed of genes involved in CD40 signaling (MAP3K14 (NIK), ICAM1, PIK3CD, NFKB2 (p52), and JAK3), regulation of epithelial-mesenchymal transition (FZD8, TCF4, PIK3CD, NFKB2, and JAK3), and NFκB and PI3K signaling (MAP3K14, TLR5, PIK3CD, JAK3, and NFKB2), pathways shown to be activated in NPC (Fig 4A-4). The gene discussed is TCF4; the disease is nasopharyngeal carcinoma.