The upregulated genes were predicted to lead to increased DNA repair and included the helicases DNA2, SMARCB1 and SMARCC; DNA repair genes MSH6, MCM6, and XRCC5; increased RNA transactivation and included transcription regulators GTF2H3, CCNT1, RARA, KHDRBS1, VOPP1 and NFE2L1; increased viral infection, and decreased survival (S3A Table). The gene discussed is KHDRBS1; the disease is viral infectious disease.