The heat map also revealed an area with 90 genes which were down regulated in the EBV positive gastric and NPC tumors when compared to the EBV negative gastric tumors, and contained genes including CTSE (cathepsin E), CXCL17, ITB7 (integrin β7), PIGR, TNFS12, MUC5B (mucin), and TRPV2 that are involved in inflammatory response and movement of antigen presenting cells (Fig 4A-2). This evidence concerns the gene CTSE and nasopharyngeal carcinoma.