Moreover, clofibrate, a PPAR-α agonist, was also confirmed to protect the heart from myocardial ischemia-induced oxidative damage by increasing expressions and activities of antioxidant enzymes, including SOD and CAT, as well as by decreasing expressions of angiotensin (Ang) II and the Ang II type 1 receptor [28]. Here, SOD1 is linked to myocardial ischemia.