After integrating the results of the GO, KEGG and PPI network analyses, we identified 5 hub genes that were closely related to PAAD tumorigenesis, namely, C-X-C Motif Chemokine Receptor 4 (CXCR4), Hypoxia-Inducible Factor 1 Subunit Alpha (HIF1A), Zinc Finger E-Box Binding Homeobox 1 (ZEB1), Syndecan 1 (SDC1) and Twist Family BHLH Transcription Factor 1 (TWIST1). The gene discussed is HIF1A; the disease is pancreatic adenocarcinoma.