En un estudio anterior, se reportó que la leptina inducía la activación de las cinasas FAK y Src en células MFC10A y en células cancerosas mamarias (Juárez-Cruz JC, García-Rodríguez E, Castañeda-Saucedo E, Mendoza- Catalán MA, Villegas S, et al. Leptin induces cell migration, gelatinases secretion and invasion in a FAK-Src dependent pathway in breast cancer cell. Here, PTK2 is linked to breast cancer.