Fibrosis regression was associated with lower baseline insulin level (20 vs 33 μU/mL; P = .02) and decrease in all NAS components (steatosis grade −0.8 [0.1] vs −0.3 [0.9]; P < .001; lobular inflammation −0.5 [0.8] vs −0.2 [0.9]; P < .001; ballooning −0.7 [1.1] vs −0.1 [0.9]; P < .001). The gene discussed is INS; the disease is fibrosis.