Consistent with our microCT observations we found a significant impact of loss of Jcad on the development of atherosclerosis in the inner curvature, with progressive reduction in atherosclerosis observed between wild type (5.33 ± 0.52 mm2; Jcad+/+ApoE−/−), heterozygous (3.80 ± 0.36 mm2; Jcad+/−ApoE−/−), and homozygous (1.78 ± 0.50mm2; Jcad−/−ApoE−/−) mice (Figure 4B and C). The gene discussed is JCAD; the disease is atherosclerosis.