JCAD and coronary artery disorder: The JCAD protective allele is associated with reduced JCAD expression, as demonstrated by Jones et al.3 (2018) who showed that the lead CAD-associated SNP (rs2487928) is a highly significant eQTL for JCAD expression in aortic and internal mammary artery tissue and Xu et al. 12who observed the same association for rs9337951.