The median MFSD2A level was 31.77 ng/ml (range, 5.40–183.66) in 21 HCC patients, 52.13 ng/ml (range, 24.12–129.13) in 16 HBV-infected controls and 52.38 ng/ml (range, 27.10–718.90) in 22 HCs. This evidence concerns the gene MFSD2A and hepatocellular carcinoma.