RM ANOVA, controlling for time and variability of measures, showed BDNF to be higher in people with CFS (F = 11.013, P = 0.002; 17.23 [4.45] ng/mL vs 14.03 [3.89] ng/mL). The gene discussed is BDNF; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.