Although associated with severe side effects such as agranulocytosis and with a yet unclear pharmacological mechanism of action, dipyrone is commonly used as a first-choice nonopioid analgesic.7 The analgesic effect of dipyrone is strongly reduced in mice lacking TRPA1,12 and it was suggested that this effect is due to a dipyrone-induced inhibition of TRPA1. This evidence concerns the gene TRPA1 and Absence of circulating granulocytes.