To investigate the role of DKK2 in human pancreatic ductal adenocarcinoma, we first compared the mRNA expression level between tumor tissue and adjacent normal tissue in GEO database GSE15471, the Oncomine Badea pancreas data, The Cancer Genome Atlas (TCGA) data, and Genotype-Tissue Expression (GTEx) data. Here, DKK2 is linked to pancreatic ductal adenocarcinoma.