Several studies revealing that cytokine response of TB with DM versus without DM following in vitro stimulation of immune cells with purified mycobacterial antigens indicate that the secretion of IFNγ has been evaluated; however, results are contraindicated with studies showing either no difference [53] or lower [60] or higher [61, 62], and the difference may be due to types of stimulating antigen and pool of MTB region of difference. The gene discussed is IFNG; the disease is tuberculosis.