These results suggested that miR-708 could potentially inhibit FOXO1 phosphorylation and then activate FOXO1-induced apoptosis by reducing SESN3, while NE differentiation of PC cells could influence FOXO1 activity through both miR-708/SESN3 and AKT pathways (Fig. 4e). This evidence concerns the gene FOXO1 and pachyonychia congenita.