For example, TGF-β is dysregulated in colorectal cancer with similarity to those noted in the bone marrow, including downregulation ofBmp2 andBmp5144; ACVRL1 overexpression is also observed in colorectal cancer, where it has been suggested as a prognostic biomarker for the metastatic phase145; and TGF-β and its signaling crosstalk play a crucial role during the endothelial mesenchymal transition, which promotes the metastatic phase of various solid tumors, particularly in breast and pancreatic carcinoma146. The gene discussed is ACVRL1; the disease is colorectal cancer.