As shown in Figures 3(b)–3(d), diabetes markedly decreased Akt phosphorylation on ser473 and STAT3 phosphorylation on Tyr705 but slightly decreased STAT3 phosphorylation on ser727, without influencing total Akt and total STAT3 expression at baseline, resulting in a markedly decreased ratio of phosphorylated Akt to total Akt and phosphorylated STAT3 to total STAT3. The gene discussed is AKT1; the disease is diabetes mellitus.