HTRA1 and age-related macular degeneration: In this study, we limited our study to genes in biological pathways relevant to AMD pathogenesis, including the complement system regulation (CFI) [36], extracellular matrix deposition and angiogenesis (HTRA1) [12], increased vascular permeability (VEGFA) [39], or degradation of the extracellular matrix (TIMP3) [11].