Furthermore, allele frequencies are known to vary with latitude depending on the region; for this reason, we aimed to determine associations between the HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 gene polymorphisms and the development of AMD in the Lithuanian population. Here, CFI is linked to age-related macular degeneration.