The authors therefore could provide groundbreaking evidence emphasizing for the first time the relevance of the Gas6/Axl pathway also during the development of ALD- and CHC-induced liver damage, supporting Gas6 and sAxl serum levels as indicative parameters of hepatic dysfunction and fibrosis development in liver disease and suggesting their possible future prognostic role within a patient multidimensional evaluation [90]. The gene discussed is GAS6; the disease is cryohydrocytosis.