In contrast to many studies showing high TIMP-2 expression in neoplastic cells with lymph node invasions, a study by Iniesta P. et al. (2007) confirmed a decrease in TIMP-2 measurements along with increased MMP-2 levels concurrently in non-small-cell lung carcinoma (NSCLC) patients (32). Here, TIMP2 is linked to non-small cell lung carcinoma.