Consequently, the recognition of TLR4 on antigen-presenting cells enhances antigen-specific antitumour immunity [119, 120], and an immunotherapeutic regimen capable of eliminating large, established mouse tumours has been developed using HMGN1, a DC-activating TLR4 agonist that is capable of inducing antitumour immunity [121]. The gene discussed is TLR4; the disease is neoplasm.