There were 14 pathways enriched with genes targeted by the four miRNAs, among which the most statistically significant pathway was the tumor necrosis factor (TNF) signaling pathway (p < 1.54 × 10−4), and other pathways (p < 0.001) included the AGE-RAGE signaling pathway in diabetic complications, mammalian target of rapamycin, sphingolipid, Chagas disease, influenza A, Toll-like receptor, and T2DM signaling pathways. The gene discussed is TNF; the disease is Chagas disease.