Compared with DM patients without MetS, those with MetS showed a much higher proportion of women (P=0.008) and as expected more hypertension (P < 0.001); higher SBP (P < 0.001) and DBP (P < 0.001); higher WC (P < 0.001); higher BW (P < 0.001), BMI (P < 0.001), and body fat mass (P < 0.001); higher fasting glucose (P=0.004), HbA1c level (P=0.005), UACR (P < 0.001), TG (P < 0.001), insulin level (P < 0.001), and HOMA-IR (P < 0.001); and lower HDL-C concentrations (P=0.003) and eGFR (P=0.003). The gene discussed is INS; the disease is hypertensive disorder.