Our present study revealed that the FGF21 value has correlation with obesity and dyslipidemia parameters such as BMI, WC, body fat mass, and serum TG, HDL-C, and LDL-C levels in the univariate linear regression analysis in T2DM patients and that body fat mass and serum log-TG levels still had positive association with serum FGF21 level even after performing multivariate linear regression analysis, indicating the phenomenon of FGF21 resistance exists in T2DM populations. This evidence concerns the gene FGF21 and obesity due to melanocortin 4 receptor deficiency.