Thus, the aims of our study were to evaluate the serum levels of calprotectin and calgranulin C in adult patients undergoing surgery for malignant and benign pancreatic tumors and to test whether these proteins are better predictors of complications of pancreatic surgery than the biomarkers currently in use, including the CRP level, WBC count, and AMS in the pancreatic drainage fluid. This evidence concerns the gene S100A12 and benign neoplasm of pancreas.