In this study, we confirmed that CDR1as was downregulated in periodontal ligament tissues with periodontitis as well as PDLSCs under an inflammatory state induced by P. gingivalis-derived LPS compared to their corresponding counterparts, indicating CDR1as may mediate the process of periodontitis and have potential effects on the functions or characteristics of PDLSCs. This evidence concerns the gene LINC00632 and periodontitis.