To further add to the ambiguity, a recent study by Canesso et al. observed that STING was required for intestinal homeostasis and the control of inflammation and that the loss of STING worsened DSS-induced colitis17, whereas in contrast, Ahn et al. reported that STING-deficient mice are rescued from spontaneous colitis in IL-10 deficient mice18. Here, STING1 is linked to colitis.