PDK1 and colorectal cancer: This counterintuitive result was well exemplified by the cases of ZEB2 and RAS in the EMT regulatory network (Fig. 5), IRS in the signaling network of EGF-EGFR and insulin-IR (Fig. 6), MEK and GRB2 in the signaling network of T-LGL leukemia survival (Supplementary Figs S5, S6), p21 and PDK1 in F2013 (Supplementary Figs S7, S8), and MEK in C2016 (Supplementary Figs S9–S11) colorectal cancer networks.