This counterintuitive result was well exemplified by the cases of ZEB2 and RAS in the EMT regulatory network (Fig. 5), IRS in the signaling network of EGF-EGFR and insulin-IR (Fig. 6), MEK and GRB2 in the signaling network of T-LGL leukemia survival (Supplementary Figs S5, S6), p21 and PDK1 in F2013 (Supplementary Figs S7, S8), and MEK in C2016 (Supplementary Figs S9–S11) colorectal cancer networks. The gene discussed is IARS1; the disease is T-cell large granular lymphocyte leukemia.