The genes with higher differences between TP and TP-ART were the IRG IFI27, the antisense RNA ARMCX3-AS1 and ZNF275. Five known anti-HIV IRGs were overexpressed in patients before ART including EIF2AK2, ISG15, APOBEC3A, MX2 and OAS1, as well as other members of the OAS family, such as OAS2, OAS3 and OASL. Five genes annotated as genes related to HIV-1 infection or resistance to AIDS were identified, including CCL2, CX3CR1, TRIM22, SIGLEC1 and TLR7. The gene discussed is ISG15; the disease is HIV-1 infection.