TLR3 and neoplasm: Indeed, in the distribution of TLR3 in our NSCLC INT cohort by IHC, 60% of TLR3-expressing cases contained over 50% of positive tumor cells; in contrast, TLR3-s-positive cases harbored no more than 25% of positive immune cells, indicating that more TLR3 mRNA originated from the tumor compared with the stroma.