TLR3 and neoplasm: Moreover, in smokers a trend towards a worse prognosis and TLR3 protein expression in the tumor infiltrate was observed (p = 0.0856; HR = 1.497; CI = 0.945–2.372) (Supplementary Fig. 2B) and also considering cases expressing TLR3 on immune cells and not on tumor cells (p = 0.0463 Wilcoxon test) (Supplementary Fig. 2C).