In agreement with what observed in IHC analysis, considering smoking habit, TLR3 was strongly significantly associated with good OS in smokers stage I NSCLC (p < 0.01; HR = 0.38; n = 267) (Fig. 4D) and not associated in no smokers (p = 0.52; HR = 0.69; n = 119) (Fig. 4E). The gene discussed is TLR3; the disease is non-small cell lung carcinoma.