CRHR2 and major depressive disorder: In our first round of models, in which genetic PCs were not examined, we identified seven CpG sites that significantly predicted onset of MDD at FDR adjusted p < 0.2, corresponding to a nominal p < 0.01, in NR3C1, CRH, CRHR1, and CRHR2. In a second set of analyses, in which we covaried for genetic variation using PCs, we found that these same CpG sites remained significant in the prediction of MDD.