CRH and major depressive disorder: In the present study, we examined whether DNAm levels at loci within six genes that have been implicated in HPA-axis functioning (i.e., FKBP5, NR3C1, NR3C2, CRH, CRHR1, and CRHR2) prospectively predict the onset of MDD in a sample of 77 girls at low and high familial risk for MDD, who had no past or current MDD diagnosis at baseline.