MIR4435-2HG and hepatocellular carcinoma: To further investigate the potential target genes involved in LINC00978-meidated HCC progression, we determined the expression of proliferation and EMT related genes that have been verified to be regulated by lncRNA through EZH2 in LINC00978 knockdown HCC cells and chose p21 and E-cadherin as targets for further study (Fig. 4c).