Statistical analysis of protein levels in HCC tissues revealed that PEDF expression was positively associated with the expression of FASN, the key enzyme in DNL pathway, whereas it was negatively associated with the activation of AMPK (pAMPK) and the expression of CPT1α, the key enzyme in FFA oxidation pathway (Fig. 4i). The gene discussed is FASN; the disease is hepatocellular carcinoma.