Although exogenous PEDF has been reported to inhibit HCC tumor growth through restraining MVD and vascular endothelial growth factor (VEGF) expression9–12,33, recent studies found high expressions of PEDF in HCC patients, and that PEDF could inhibit HCC cell apoptosis13 and promote HCC metastasis14. Here, SERPINF1 is linked to hepatocellular carcinoma.