A protective role of IL-37 in human malignancies, including fibrosarcoma, cervical cancer, hepatocellular carcinoma, breast cancer, and non-small-cell lung cancer, via the regulation of signaling pathways has also been reported, e.g., suppression of nuclear factor-κB and MAPK and activation of the Mer–PTEN-DOK pathway37. This evidence concerns the gene PTEN and breast carcinoma.