Primary epithelial cells isolated from p65f/f and p65ΔM/ΔM mice confirmed that NF-κBp65 deficiency in gastric myeloid cells evidently inhibited the levels of Fas, the activation of caspase-3 and the phosphorylation of NF-κBp65 in epithelial cells from PVL mice, although few FasL was detected in the epithelial cells in both p65f/f and p65ΔM/ΔM mice (Fig. 6d). The gene discussed is CASP3; the disease is periventricular leukomalacia.