FAS and colon carcinoma: While, IL-6 could not directly mediate epithelial cell Fas induction and apoptosis by utilizing primary epithelial cells and the gastric epithelial cell lines, GES-1, although it was reported that IL-6 involved in regulating apoptosis resistance in immune and non-immune cells, such as hepatocytes, myeloma cells, and colon carcinoma cells31,32, which may be related to the different cell types, tissue microenvironments and receptor/signaling system of diverse disorder states, which indeed merits further evaluation.