SQSTM1 and neoplasm: In our study, IHC staining showed increased LC3B, P62 of cytoplasm level in the tumor isolated from the mice with injection of circCDR1as cells in experiment groups compared to the control groups; while the data from western blotting analysis detected the ratio of LC3II/I was increased, and P62 levels was downregulated in circCDR1as-overexpressed cells under hypoxic condition compared to those in normoxia-culturing conditions.