In particular, PHFtau-tangles, histone coacetylation module (m434), expression levels of miR-132 and miR-129-5p, and protein abundance of VGF and IGFBP5 showed stronger effects on either global parkinsonism score or dexterity (Fig. 3b) and potentially formed regulatory cascades contributing to motor impairment (Fig. 4). The gene discussed is IGFBP5; the disease is Parkinson disease.