IGFBP5 and Parkinson disease: In this comparison, we identified three brain pathologies (PHFtau-tangles, arteriolosclerosis, and nigral neuronal loss), four histone coacetylation modules (m28, m117, m434, and m450), three miRNAs (miR-132, miR-129-5p, and miR-129-3p), and three proteins (IGFBP5, VGF, and SYT12) that were associated with either global parkinsonism, dexterity, or both (p < 8.9 × 10−5) (Fig. 2a and Supplementary Table 7).