In particular, PHFtau-tangles, histone coacetylation module (m434), expression levels of miR-132 and miR-129-5p, and protein abundance of VGF and IGFBP5 showed stronger effects on either global parkinsonism score or dexterity (Fig. 3b) and potentially formed regulatory cascades contributing to motor impairment (Fig. 4). This evidence concerns the gene VGF and Parkinson disease.