IGFBP5 and Parkinsonism: In particular, PHFtau-tangles, histone coacetylation module (m434), expression levels of miR-132 and miR-129-5p, and protein abundance of VGF and IGFBP5 showed stronger effects on either global parkinsonism score or dexterity (Fig. 3b) and potentially formed regulatory cascades contributing to motor impairment (Fig. 4).