More importantly, not only did LBP enhance the upregulation of the PERK pathway induced by 125I, the inhibition of tumor growth in mouse tumor model treated with combined treatment was compromised when PERK-siRNA was transfected into HCC cells, which might explain the mechanism by which LBP promotes the radiosensitivity of HCC cells to 125I. The gene discussed is EIF2AK3; the disease is hepatocellular carcinoma.