To investigate whether the 125I-induced anti-proliferative effect on HCC cells was promoted by LBP, a cell proliferation assay, cell cycle assay, and EdU assay were performed for both HepG2 and SMMC7721 cells treated with 125I, LBP, or a combination of the two (Fig. 2). The gene discussed is LBP; the disease is hepatocellular carcinoma.