Among the significantly enriched signaling pathways from KEGG analysis, oxytocin signaling pathway (PATH:04921; Cacng2, Adcy1, Kcnj4, Kcnj9, Adcy8, Pik3cd, Elk1, Adcy4, Camkk2, Cacng7, Nos3, Kcnj2) may play an important role in the sevoflurane-induced cognitive impairment. This evidence concerns the gene ADCY8 and Cognitive impairment.